At The Age Of 21 Regina Cassandra Acted a Tamil Love Short Film .She Acted Many Tamil Movies . In 2012, she appeared in Shiva Manasulo Shruti by Tatineni Sathya, which was a remake of the 2009 Tamil film Siva Manasula Sakthi. She was next seen in the Telugu romantic-comedy, Routine Love Story, alongside Sundeep Kishan. She Got SIIMA Award for Best Female Debutant in Shiva Manasulo Shruti Movie.
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